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Year : 2014  |  Volume : 8  |  Issue : 2  |  Page : 44-49

Comparison of the analgesic effect of Ibuprofen and pulsed low-level laser in reducing pain after orthodontic separator placement and evaluation of the changes in the sulcular pain especially prostaglandin E2 level

1 Orthodontist, Private Practice, Tehran, Iran
2 Department Orthodontic, Student Research Committee, Orthodontics Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
3 Orthodontist, Private Practice, Tehran; Department Orthodontic, Student Research Committee, Orthodontics Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Immunology, Infertility Research Center, Shiraz Proteomics laboratory, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Fateme Bahramnia
Department of Orthodontics, School of Dentistry, Orthodontics Research Center, Shiraz University of Medical Sciences, Shiraz
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-2868.145137

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Background : Non-steroidal anti-inflammatory drugs such as Ibuprofen have long been used as a relief to orthodontic pain, and low-level laser therapy (LLLT) has been recommended for the analgesic effects. Objective : The purpose of this study was to compare the analgesic effects of Ibuprofen and LLLT on orthodontic pain and prostaglandin E2 (PGE2) level assessment in gingival crevicular fluid (GCF). Subjects and Methods: A total of 28 volunteered dental students (14 male; 14 female) were randomly divided into LLLT group and Ibuprofen group. Maxillary first molars were randomly selected to place separators in mesial and distal contacts. One group received Ibuprofen administration and the other received pulsed low-level GaAlAs laser irradiation. GCF samples were collected before therapeutic interventions and 1 h and 24 h later. Pain intensity was analyzed before therapeutic intervention and 1 h and 24 h later using visual analogue scale (VAS). Statistical analyses were Mann-Whitney U-test, t-test, Friedman test, and repeated measures ANOVA test. Results: Based on VAS scores both groups experienced increasing pain within 24 h. A significant reduction was found in PGE2 levels after 1 h and an insignificant reduction after 24 h in Ibuprofen group, but in the laser group no significant change was observed in PGE2 levels (P < 0.05). Conclusions : The current study showed that pulsed low-level laser did not have any analgesic effect and Ibuprofen was most effective 1 h after administration. There was no difference in analgesic effects of laser and Ibuprofen, and no correlation was found between PGE2 levels of GCF and pain perception.

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